For Humans
According to the National Fire Protection Association's (NFPA) 2001 Clean Agent Fire Extinguishing Systems report, 12% minimum oxygen corresponds to NO adverse effect level in humans and 10% corresponds to LOW adverse effect level in humans. Prevenex systems never go below 12% oxygen levels.

For the Environment
Hypoxic fire prevention and suppression is approved under the Environment Protection Agency's (EPA) Significant New Alternatives Policy. The EPA states that this technology "does not require further review and can be marketed" and that it has a "zero toxicity and zero atmospheric damage factor."

For Aviation
The Federal Aviation Administration (FAA) and United States Department of Transportation (USDOT) has conducted research to show that hypoxic conditions can prevent ignition of fuel tanks on airplanes, decreasing the risk of fire and explosions.